Bringing science and development together through original news and analysis

  • Swine flu science update: 5 November 2009

At least 16 of the world's poorest countries will receive batches of the A(H1N1) swine flu vaccine within the next few weeks [57kB], the WHO says.

Marie-Paule Kieny, the WHO's director of vaccine research, told a press briefing last week (30 October) that 156 million vaccine doses have been secured, largely through donations, and these will be distributed to 95 developing nations.

In line with recommendations from SAGE (Strategic Advisory Group of Experts on Immunization), health care workers will be vaccinated first.

Populations will need reassurance that the vaccine is safe, now that mass immunisation campaigns are underway, notes an article in The Lancet* last week(31 October).

The authors warn there is a tendency for the public to link new vaccines to unrelated but highly visible conditions such as spontaneous abortion, Guillain-Barr syndrome or even death when immunisation campaigns are not accompanied by reliable safety data.

However, at the same time, public health officials need to be on the lookout for serious adverse events resulting from new vaccines, the article says.

Ponies were used to deduce just how the influenza virus outwits the flu vaccine to cause illness in a study published in Science last week (30 October). Researchers studied vaccinated and non-vaccinated ponies infected with equine influenza and showed how changes in the amino acids of a virus' hemagglutinin protein (one of the main ways the virus evades the immune system) influence disease spread.

They say that following the molecular evolution of the influenza virus could inform the development of more effective vaccination strategies. They also point out that even an imperfect vaccine could be beneficial if enough of a population is vaccinated.

In a similar study reported by The Associated Press last week (29 October), scientists found that regular immunisations against flu result in mice becoming infected by a 'stickier' version of the virus. Stickiness reflects mutations to the virus in response to 'antibody pressure' from the host's immune system but a sticky flu strain does not spread as easily.

A controversial theory proposing that small children who fall ill with seasonal influenza will develop better immunity to A(H1N1) was published online in The Lancet Infectious Diseases* (30 October). Scientists from the Erasmus Medical Centre in the Netherlands debated the issue with colleagues from Finland's Turku University Hospital.

The Dutch researchers argued that catching type-A seasonal flu strengthened children's immune systems against A(H1N1) but the Finns disagreed, saying the benefits of vaccination far outweighed any theoretical risks.

Thermal screening is in place in Saudi Arabia's airports [8.3MB] to detect feverish passengers travelling to join the Hajj pilgrimage later this month. This measure, along with others designed to stop the spread of A(H1N1) during the Islamic pilgrimage, was outlined in an article in Science last week (29 October).

The Saudi health ministry, in collaboration with the US Centers for Disease Control and Prevention, plans to establish an influenza surveillance system involving mobile phones and the internet. Analysis of specimens will be carried out between Saudi Arabia's ministry of health and the US Naval Medical Research Laboratory.

*Free registration required to view this article

SciDev.Net's regular swine flu science updates are part of the swine flu subtopic which offers up-to-date news, opinions and features on swine flu and the developing world.

You can also receive the latest on swine flu from SciDev.Net by signing up to our RSS feed or subscribing to our weekly email alert.

Republish
We encourage you to republish this article online and in print, it’s free under our creative commons attribution license, but please follow some simple guidelines:
  1. You have to credit our authors.
  2. You have to credit SciDev.Net — where possible include our logo with a link back to the original article.
  3. You can simply run the first few lines of the article and then add: “Read the full article on SciDev.Net” containing a link back to the original article.
  4. If you want to also take images published in this story you will need to confirm with the original source if you're licensed to use them.
  5. The easiest way to get the article on your site is to embed the code below.
For more information view our media page and republishing guidelines.