This guide, published by the International Atomic Energy Agency, offers practical advice for policymakers, managers and advisers in countries that are setting up their first nuclear power plant, or those restarting an inactive nuclear programme. It provides information about the activities, responsibilities and desired attributes of those running nuclear plants, whether private companies or the state. It also describes the experience of countries that have built and operated nuclear power plants, and outlines how the owner and operator should interact with national authorities, nuclear and environmental regulatory bodies, the national grid, waste management, and emergency planning and response organisations. The report also provides examples of contracts that can be used in the process of setting up a power plant.