The paper investigates the gap between the scientific or research community and the policymaking community in South Africa. It proposes a model of knowledge brokering as a means to bridge the gap and ensure the uptake of evidence in policy development and implementation. The model looks at the need for institutional mechanisms, such as knowledge-brokering offices in research organisations and government. It highlights the importance of researchers involving policymakers from the outset as well as increasing dialogue between these communities.