This collection of 43 essays is by people involved in HIV/AIDS research, community education, clinical trials and advocacy, and aims to both inform and encourage global action. Written in an easy-to-read style, it introduces many of the major scientific, policy, social, ethical and economic challenges of developing an AIDS vaccine, with chapters covering issues such as HIV vaccine science, vaccine safety, ethics of clinical trials, informed consent, community action to encourage HIV vaccine development, and sources of information and help. Notable contributions from developing country authors include the personal experiences of a vaccine scientist involved in establishing the first HIV vaccine trials in Uganda, the vulnerability of women to HIV/AIDS in India , and the challenges of recruiting women to participate in clinical trials in Kenya. Illustrations include photographic accounts of the HIV virus and its life cycle, and clinical and laboratory tests on clinical trial volunteers.