Study points to plethora of malaria drug targets
The malaria parasite
The proteins, known as 'transit peptides', interact with special structures in the parasite's cells called plastids. Because human cells do not contain plastids, drugs that interfere with the action of these proteins can shut the parasites down without harming humans. Until now, however, transit peptides have been poorly understood and difficult to identify.
In this week's issue of Science, Bernardo Foth from the University of Melbourne, Australia, and colleagues report that they analysed hundreds of proteins from the malaria parasite and identified certain features unique to transit peptides. They then created artificial versions that lacked these characteristics and found — as expected — that the peptides could no longer work properly.
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Link to paper in Science by Bernando Foth et al
Photo credit WHO/MAP/TDR