Bringing science and development together through news and analysis

  • Malaria parasite 'could develop resistance to key drug'

Shares

Malaria could easily become resistant to artemisinins, the latest and most effective drugs against the parasite, researchers warned this week.

The team's research, published online on 5 June by Nature Structural and Molecular Biology, shows how Plasmodium falciparum, the parasite that causes malaria in humans, could mutate and become immune to the drugs.

Sanjeev Krishna at St George's Hospital Medical School in London, United Kingdom, who led the research, and his team suggested in 2003 that artemisinins work by blocking a parasite protein that carries calcium in and out of cells.

As a result, said the researchers, calcium builds up, killing the cells. At the time, their findings were received with some scepticism.

Now, the same team has published further research supporting this theory. They add that a small change in the calcium carrying protein could make the parasite resistant to the drugs.

The scientists used laboratory techniques to change a small detail of the protein's structure and found that artemisinins were no longer able to block it.

Krishna told SciDev.Net that the international scientific community should actively begin to look for signs of resistance in wild forms of malaria now, rather than "play catch-up".

"History has shown us that resistance has developed to all other malaria drugs; it would be negligent not to take our experience into account."

He adds that although it is difficult to say when P. falciparum might become resistant to artemisinins, the likelihood of this happening increases as more and more people use the drugs.

Krishna says sites should be monitored across Africa and other places where artemisinin-based therapies are being provided by institutions such as the World Health Organization (WHO).

He added that in addition scientists should try to "design their way out of this [problem]".

For example, the next generation of artemisinin-based drugs could be designed to affect the malaria parasite in a different way.

Artemisinin became the WHO 'drug of choice' against malaria in 2001.

Since then significant efforts have been made to increase its use worldwide.

Reference: Nature Structural and Molecular Biology 2005 (online), DOI: 10.1038/nsmb947

Republish
We encourage you to republish this article online and in print, it’s free under our creative commons attribution license, but please follow some simple guidelines:
  1. You have to credit our authors.
  2. You have to credit SciDev.Net — where possible include our logo with a link back to the original article.
  3. You can simply run the first few lines of the article and then add: “Read the full article on SciDev.Net” containing a link back to the original article.
  4. If you want to also take images published in this story you will need to confirm with the original source if you're licensed to use them.
  5. The easiest way to get the article on your site is to embed the code below.
For more information view our media page and republishing guidelines.