Bringing science and development together through news and analysis

  • Boosting treatment 'could halt HIV in five years'

Shares

Clinical trials of a universal 'test and treat' strategy that could see the HIV pandemic halted within 5–10 years are soon to begin, the American Association for the Advancement of Science meeting in San Diego heard yesterday (21 February).

Small-scale trials in Canada, South Africa and the United States will examine the assumption that testing everyone in a target population, and giving antiretroviral drugs (ARVs) immediately to those who are positive, will stop transmission of the disease, Brian Williams of the South African Centre for Epidemiological Modelling and Analysis told the meeting.

Currently ARVs are prescribed once a blood test reveals that HIV is damaging a patient's immune system.

Modern ARVs vastly reduce the amount of HIV in the blood — by about 10,000-fold, said Williams. In doing so, they reduce infectivity by about 25-fold, and Williams and colleagues have calculated that if all HIV patients took them, transmission of HIV would stop within five years.

The strategy would be expensive — US$3–4 billion a year for South Africa alone — and would rely on people's willingness to be tested and take a lifelong course of drugs, said Williams.

There are also fears that such mass drug treatment would increase drug resistance to ARVs (see 'Test and treat' HIV strategy could backfire) although there is evidence that patients are developing less resistance to the latest ARVs than they did to first-generation drugs.

Republish
We encourage you to republish this article online and in print, it’s free under our creative commons attribution license, but please follow some simple guidelines:
  1. You have to credit our authors.
  2. You have to credit SciDev.Net — where possible include our logo with a link back to the original article.
  3. You can simply run the first few lines of the article and then add: “Read the full article on SciDev.Net” containing a link back to the original article.
  4. If you want to also take images published in this story you will need to confirm with the original source if you're licensed to use them.
  5. The easiest way to get the article on your site is to embed the code below.
For more information view our media page and republishing guidelines.