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  • Monkey puzzles in AIDS vaccine research

The number of AIDS vaccines moving through the pipeline toward clinical trials has increased over recent years.

But significant scientific and operational challenges remain, not least because a slew of experiments in monkeys — the favoured model for testing vaccine strategies — has raised questions about most of the vaccine approaches now being pursued.

As a result, some scientists fear that none of the vaccines now in human trials will work.

Reference: Science 296, 2325 (2002)

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