This report provides policy recommendations to help deliver safer and cheaper medical products to people suffering from neglected diseases in developing countries, where they are needed the most.

Although more drugs and vaccines are reaching late-stage clinical development, says the report, they are held back by a lack of funding to support clinical trials, as well as clinical research and regulatory capacity in settings where neglected diseases are endemic. This undermines safety and the validity of clinical data.

The report recommends a two-pronged approach to improving the quality and regulation of clinical trials in the developing world: establishing regional regulatory pathways for the oversight of clinical trials, and building quality and cost-efficiency into trial design and implementation. It also recommends practical steps that can be taken by donors, drug and vaccine developers, and regulatory authorities to begin implementing the changes.

This report assesses the relevance and applications of 'complexity science' — a term that encompasses inter-relationships between different disciplines and objectives in international development projects. It provides a definition, gives examples of actual and potential applications, and identifies future possibilities and challenges.

The report focuses on how to apply the methodologies of complexity science — such as nonlinear dynamics, stochastic processes, agent-based models and machine learning — to study complex systems such as climate change and economic forecasts. It examines several areas of complexity science in detail, showing how they are likely to be beneficial for a range of international development scenarios, and offers an example of success in the automated use of data to improve the rate of correctly classifying soybean disease. It concludes that increasing the availability of data will make complexity science increasingly important, raising questions about how to best use this data and improve their availability and reliability.

This paper suggests that research-based, small-scale interventions that help farming systems adapt to climate change can guide progress towards achieving food security and addressing the food crisis in the Horn of Africa.

It outlines lessons learnt from the Climate Change Adaptation and Development Programme jointly implemented by the UN Environment Programme and the UN Development Programme for Sub-Saharan Africa.

The authors argue for a shift away from top-down, corporate approaches to agricultural research and practice, in favour of a democratic approach that involves giving more decision-making power to local people, including farmers and indigenous people. Small-scale initiatives reduce tillage, protect the soil surface and alternate cereal crops with legumes that enrich the soil.

The paper suggests that communicating food security solutions to the public can help balance vested interests and level the field in favour of small producers. Managed effectively, the current drought in the Horn of Africa offers a window of opportunity to re-establish food security as a global priority.

This report synthesises the results of a review of 104 studies on gender and the adoption of agroforestry in Africa, and aims to identify strategies that challenge gender imbalances in development initiatives. It explores women's participation in agroforestry, including their ability to manage agroforestry practices, access to agroforestry information, and how they benefit from agroforestry.

The results highlight the substantial benefits that agroforestry can offer to rural women in Africa, mainly because it requires fewer resources than alternative enterprises. But women's participation is low, with limited access to information and markets, and a mixed record of successful management of agroforestry technologies.

The report provides several technological, policy and institutional recommendations for improving the efficiency of women's participation in agroforestry. They include domesticating important tree species, and ensuring that women have access to market information and microfinance. The report concludes by suggesting further research in areas such as measuring the income that women generate from agroforestry, and identifying the key ingredients of success stories across Africa.

This report highlights advances in the use of climate information to predict and prepare for climate-related natural disasters. It draws together 17 case studies that capture the current state of knowledge within the humanitarian community, and identifies research innovations. It presents the challenges and opportunities that disaster risk managers face in using climate science with a three step approach: indentifying the problem, developing tools, and taking action.

The results show that effective partnerships are crucial and can help to build the information needed for effective response. They also suggest how the use of this information can be improved — for example by focusing on immediate opportunities for action in countries and regions more likely to benefit. Recommendations also include developing realistic expectations, in order to maintain trust in the information and those who provide it, and encouraging national meteorological services to tailor their information to the problem at hand.

This technical report provides policymakers with a framework for action to address the underlying causes for the science and technology (S&T) gender gap, and aims to promote discussion about gender in the scientific and academic communities.

The report provides an overview of S&T for development and discusses how gender can be incorporated into S&T education, research and policy. It incorporates empirical data and research contributed by institutions involved in science, technology and gender studies and policy around the world. It highlights the need to increase women's participation in S&T research, foster awareness about science, technology and gender among the general public, and collect more data for research.

The full report is available in English but Arabic, Chinese, Spanish and Russian versions are being prepared. An executive summary is available in English, French, Arabic and Chinese. It is the first of several planned thematic reports to be produced by the UN Educational, Scientific and Cultural Organization (UNESCO).

This report presents gender-differentiated statistical data on higher education student enrolments and graduations, human resources for science and technology (S&T), publication output, funding allocation, and scientific ratings given to individual researchers by the National Research Foundation (NRF).

The study finds that South African women's participation in science education has increased, and gender parity in funding for higher education and research has improved, even in the fields of engineering and applied technologies. But women are still a minority, particularly at higher postgraduate levels, and remain behind their male counterparts in access to S&T employment, scientific publications, and NRF ratings. The report recommends action such as promoting research on 'gender responsiveness' and tackling the unequal distribution of public resources.

This study evaluates the extent to which gender perspectives have been integrated into science and technology policy in six Asian countries: China, India, Indonesia, Republic of Korea, the Philippines, and Vietnam. It aims to assess the existing level of support for the integration of gender perspectives into national and regional policy, and to identify steps that could be taken in that direction.

The paper outlines each country's situation on science, technology and gender (STG) using statistical data and information about existing laws and policies related to gender, government programmes, key institutions and current STG problems.

A comparison of the findings suggests differences in the legal and policy frameworks that countries use to ensure gender equality in science and technology (S&T). The study recommends addressing regional concerns by prioritising the collection of S&T data by gender, for example, and ensuring that the scientific community is committed to gender equality.

This report, published by the Meridian Institute describes the growing interest of developing countries including Brazil, China, India and South Africa, in nanotechnology. The ways nanotechnology applications could solve health, sanitation, and pollution problems and provide faster, cheaper information and communication technology are outlined. The challenges of using and developing nanotechnology for and in developing nations including the roles and responsibilities of different stakeholders are also discussed.

The Meridian Institute says nanotechnology can play a role in achieving the UN Millennium Development Goals. As a result, rich nations should dedicate a reasonable portion of their overseas development assistance to nanotechnology.

This report, published by Thomson Reuters, uses a collection of data to provide an overview of the patterns of research activity in Africa. The authors note the drain of talent away from the continent and suggest that this is partly due to a chronic lack of investment in research.

The authors identify networks of collaboration both within and beyond the continent but conclude that it is unclear whether these networks reflect long-term research links, or current research interests.

This report summarises current understanding of antibiotic resistance, the scope of the problem, and the methods available for detecting and preventing it. It highlights unique challenges faced by developing countries including poor research infrastructure and counterfeit antibiotics.

The authors highlight the need to build laboratory capacity, improve diagnostic tools, establish surveillance programs and implement tighter controls on antibiotic use in these countries.

This paper, published by the International Centre for Trade and Sustainable Development, reviews proposals on using intellectual property to improve access to climate change technologies and the extent to which these may help developing countries.

The author, US lawyer Cynthia Cannady, criticises the practicality of implementing compulsory licenses, patent pools or databases, and voluntary licensing for developing countries.

Instead, she suggests a two-pronged strategy that supports research in developing countries and promotes mutually beneficial technological collaboration between developed and developing countries.

Cannady recommends implementing this strategy by managing developing countries' intellectual capital, supporting local climate change research and development, improving education and awareness, commercialising climate change technology and engaging in periodic assessment.

This report, published by the Swiss Academy of Sciences (SCNAT), describes twelve projects to illustrate successful scientific partnerships between developed and developing countries.

The projects cover research into water-borne disease, natural disasters, brain drain and forest management, and include partnerships with researchers in Chad, Ethiopia, Pakistan, Thailand and Vietnam.

The report reveals how high-quality local and global scientific knowledge can lead to local development benefits. For example, collaboration between developed-country researchers and their counterparts in locations where infections are likely to arise can halt epidemics at the local level, benefiting the global sphere.

The authors suggest that future research budgets must take into account the global and cross-diciplinary nature of research and encourage scientific cooperation.

They say that approximately 85 per cent of global research and development resources are invested in countries within the Organisation for Co-operation Development (OECD), compared with just five per cent given to developing countries.

This report from the WHO assesses the potential for creating early warning systems for vector-borne disease. It reviews the current state of research for several diseases such as dengue fever, leishmaniasis, malaria and West Nile virus.

The report includes an algorithmic framework for developing early warning systems, outlining data requirements and the different components of the system. It also contains two useful tables: one on the sensitivity of different infectious diseases to climate; and one summarising the existing research, identifying in which region the disease is most common, data availability and proposed actions.

A key problem in developing early warning systems, as highlighted by this report, is that non-climatic risk factors such as population immunity and food security strongly affect the potential for a disease outbreak. Equally challenging is the poor disease surveillance in many developing countries — the authors call on these countries to strengthen these systems, to help in the fight against climate change.

The report concludes that it will be important for researchers not to design these systems in isolation — health policymakers should be included at all stages of the design.

This World Bank report describes the role higher education plays in building developing countries' capacity to participate in a knowledge-based world economy and outlines policy options to promote economic development. It confirms the shift in the World Bank's attitude to education support as a driver of socioeconomic growth.

The authors ask why higher education is important for development, how developing countries can best utilise their higher education systems, and how the World Bank and other donors can support local governments. They argue that knowledge is essential for development — and higher education is essential to create and apply knowledge.

They conclude that developing countries risk marginalisation because of their weak higher education systems, and stress the need for government and donor support.

This report, published by the Global Forum for Health Research, tracks global investments in health research and development (R&D).

The authors review global targets and commitments for R&D in health and evaluate how well these are being met. They highlight the differences in funding by region, including analyses from Argentina, China and the United States; and provide a breakdown of investments in R&D for cancer and 20 widespread infectious diseases.

They also describe the different sources of R&D funding, providing data on private, public and not-for-profit investments.

The authors discuss the implications of the current funding climate for future health research and make recommendations for improving research agendas, suggesting that R&D investments must match the health needs of developing countries now and in the future.

This report, published by the Center for International Development at Harvard University and the International Livestock Research Institute in Kenya, asks which institutions and approaches are most effective in using scientific knowledge to inform development strategies.

The authors evaluate five agricultural projects in Africa and Asia and suggest that the best strategies for closing the gaps between knowledge and action include: 'boundary-spanning' efforts such as creating partnerships to improve dialogue between researchers and local communities; 'use-driven' research directed at solving particular problems for particular groups of people; engaging stakeholders from the outset of a project; providing incentives for risk-taking; and improving project management and communication skills.

This joint publication between the World Health Organization and the Global Forum for Health Research reveals mental health research capacity in 114 low-income and middle-income countries in Africa, Asia, and Latin America and the Caribbean. The extensive review identified over 10,000 articles, 4,633 mental health researchers and 3,829 other stakeholders. The authors argue that this is "the first systematic attempt to confirm the pressing needs of improving research capacity in mental health".

The publication provides useful details in table and charts, analysed by group of stakeholders and by region, on topics such as: researchers' profiles; priority-setting process; amount and type of research production; services and technical support available to them; courses and trainings offered; funding patterns; and dissemination of research findings. The appendix provides two extensive lists — by country — of policy and practice that resulted from research evidence, as well as research evidence that was never translated into policy and practice.

Nine recommendations indicate how the management of mental health research can be strengthened so that it meets the national needs of the countries as well as contributes to the global fund of knowledge. The authors say their report thus enables evidence-based decision-making in funding and priority setting in the area of mental health research in low-income and middle-income countries.

This extensive report was one of the first to document the scale of the problem of chronic diseases in developing countries, and crucially, to offer guidance on feasible and practical methods of tackling them.

The document starts by laying out in detail the profiles of chronic diseases in different countries, projections for the future, and how chronic diseases are linked with poverty. It also examines in depth the economic costs of such diseases and the macroeconomic consequences of not tackling them quickly enough. The authors outline interventions — whether community, workplace, or school — that have robust evidence supporting them.

The report ends with a call for a unifying framework of global health experts and stakeholders, in which the government has a key role. It also specifies what policymakers need to do to ensure that measures to tackle chronic diseases are put into action.

The report summarises the results of a survey of African Universities’ experiences in collaborating with scientists and institutions in developed countries. The study was carried out by the Association of Commonwealth Universities to provide background information to support the recent development thrust aimed at strengthening African universities through greater investment and North–South (and South–South) collaboration. It focuses primarily on social sciences and humanities research. The report presents empirical data on institutional goals, resource availability, prevalence and satisfaction with collaborative arrangements, challenges faced by individual researchers, capacity building as well as training and research support.