ISESCO aims to promote the separate and distinct educational, scientific and cultural heritage that combines the 57 OIC member countries. The primary purpose of the organisation is to coordinate the activities of specialist agencies responsible for similar functions within each of the OIC member countries.

ISESCO has helped develop a number of action plans and strategies on an OIC-wide basis in areas such as water resources, university education and Islamic culture. ISESCO has also started awarding prizes in education and literacy, sciences and university research, and culture and communication to individuals within the OIC member countries.

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