SciDev.Net

This book, published by the intergovernmental organisation South Centre, presents a collection of articles on intellectual property (IP) restrictions and access to knowledge for developing countries.

An outcome of the South Centre Innovation and Access to Knowledge Programme, the book responds to pressure from IP owners to increase control over knowledge in different forms including digital platforms. 

This report from the WHO assesses the potential for creating early warning systems for vector-borne disease. It reviews the current state of research for several diseases such as dengue fever, leishmaniasis, malaria and West Nile virus.

The report includes an algorithmic framework for developing early warning systems, outlining data requirements and the different components of the system. It also contains two useful tables: one on the sensitivity of different infectious diseases to climate; and one summarising the existing research, identifying in which region the disease is most common, data availability and proposed actions.

A key problem in developing early warning systems, as highlighted by this report, is that non-climatic risk factors such as population immunity and food security strongly affect the potential for a disease outbreak. Equally challenging is the poor disease surveillance in many developing countries — the authors call on these countries to strengthen these systems, to help in the fight against climate change.

The report concludes that it will be important for researchers not to design these systems in isolation — health policymakers should be included at all stages of the design.

This journal article describes the first climate-based model used to predict outbreaks of dengue fever. Researchers from the University of Miami and the University of Costa Rica used climate data and vegetation indices from Costa Rica to predict disease outbreaks with 83 per cent accuracy.

Globally, there are up to 100 million cases of dengue fever, and its more dangerous form, dengue haemorrhagic fever, every year. The spread of dengue fever is set to rise as the world's climate changes. The importance of this model is that it could be used as the basis for an early warning system to prevent the spread of the disease by warning populations that are at risk.

The indices used in the model include variables such as El Niño Southern Oscillations and sea surface temperature, which affect populations of the Aedes aegypti mosquito that spreads the infection.

This World Bank report describes the role higher education plays in building developing countries' capacity to participate in a knowledge-based world economy and outlines policy options to promote economic development. It confirms the shift in the World Bank's attitude to education support as a driver of socioeconomic growth.

The authors ask why higher education is important for development, how developing countries can best utilise their higher education systems, and how the World Bank and other donors can support local governments. They argue that knowledge is essential for development — and higher education is essential to create and apply knowledge.

They conclude that developing countries risk marginalisation because of their weak higher education systems, and stress the need for government and donor support.

This paper from the Association of Commonwealth Universities outlines the commitments and activities made by major international partners — specifically the G8 countries — to developing African higher education between 2000 and 2004.

Projects are analysed by topic — from human resources development to HIV/AIDS to science and technology — and region. The authors highlight trends in donors' strategies for supporting African higher education, presenting development portfolios and case studies from France, Germany, Scandinavia, the United Kingdom and the United States, among others. They suggest improvements in aid delivery, including collaboration between donors and increased communication about individual donor strategies. They also call for more networking and collaboration across higher education institutions within Africa, while noting that these face financial constraints.

The authors conclude that there is a particular need for donors to provide more support to science and technology projects — as a crucial driver of socioeconomic development.

This paper examines the relative costs of research in South Africa and the apparent disparity in researchers' salaries. A 2004–2005 research and development survey provides data on the unit cost of research across higher education institutions (HEIs), science councils and the business sector. Analysis shows that research costs and salaries are highest in the business sector and lowest in HEIs, although the differences are not as wide as expected. Similarly, overhead costs are lowest in HEIs and highest in the business sector.

But the authors emphasise that while HEIs may provide the cheapest research — based on cost per hour — this does not mean that they necessarily provide the cheapest 'cost per deliverable', i.e. value to the client.

The authors call for more regular and detailed data to better understand the researcher labour market. They propose an annual salary survey focused on public sector researchers and a common pricing model for all institutions performing public research.

This paper challenges the idea that patent counts provide reliable indicators of innovation in cross-country assessments. The authors argue that national differences in patent systems — how and why patents are granted and standards of examination — make comparisons across countries difficult at best, inaccurate at worst.

They urge readers to be cautious in interpreting the World Intellectual Property Organization findings that suggest the geography of innovation is changing — based on a sharp rise in patent counts in north-east Asia. The authors' own analysis of Chinese patent applications and legal frameworks in Brazil, India, Europe and the United States shows wide differences in the value of patents across regions.

They recommend developing a proper set of indicators for monitoring innovation capacities, particularly in developing countries.

This report, published by the Global Forum for Health Research, tracks global investments in health research and development (R&D).

The authors review global targets and commitments for R&D in health and evaluate how well these are being met. They highlight the differences in funding by region, including analyses from Argentina, China and the United States; and provide a breakdown of investments in R&D for cancer and 20 widespread infectious diseases.

They also describe the different sources of R&D funding, providing data on private, public and not-for-profit investments.

The authors discuss the implications of the current funding climate for future health research and make recommendations for improving research agendas, suggesting that R&D investments must match the health needs of developing countries now and in the future.

This report, published by the Center for International Development at Harvard University and the International Livestock Research Institute in Kenya, asks which institutions and approaches are most effective in using scientific knowledge to inform development strategies.

The authors evaluate five agricultural projects in Africa and Asia and suggest that the best strategies for closing the gaps between knowledge and action include: 'boundary-spanning' efforts such as creating partnerships to improve dialogue between researchers and local communities; 'use-driven' research directed at solving particular problems for particular groups of people; engaging stakeholders from the outset of a project; providing incentives for risk-taking; and improving project management and communication skills.

This article examines the US Bayh–Dole (BD) Act — a 1980s measure that sought to stimulate science-based economic growth by encouraging universities to patent inventions resulting from government-funded research — and assesses its suitability for developing countries.

The authors look at how and why advocates of BD-type initiatives sometimes overstate its impact in the United States and discuss the problems the act has caused for American biotechnology and information technology.

They outline the policy options for developing countries seeking to improve the contributions universities make to economic development and provide a list of safeguards that should be put in place before adopting laws styled after the act. These include no exclusive licensing, transparent patenting and government authority to issue additional licenses.

The authors conclude that policies to develop public sector research and development are context-specific and it is unclear whether any of the positive impacts of BD in the United States would arise in developing countries following similar legislation.

Vaccination for infectious diseases is a vital method of prophylaxis, and has transformed modern medicine. By contrast, research into vaccines against chronic diseases has been less successful, in part because of the increased complexity involved.

In this opinion piece, the authors outline the prospects for the development of chronic disease vaccines. These might not need to rely on the traditional method of inducing the body to produce antibodies, but rather on introducing monoclonal antibodies against specific proteins — this has so far worked well against Crohn's disease and rheumatoid arthritis.

The authors outline key hurdles in developing a successful therapeutic vaccine. Safety and efficacy are two obvious ones, but there is a third that is unique to vaccines for chronic diseases. Because these vaccines would block bodily chemicals — such as cytokines or hormones — it would not be acceptable for a vaccine to induce a life-long block (unlike a malaria vaccine, for example, where a lifelong block would be ideal).

These might be particularly useful in developing countries, say the authors. Because prophylaxis with vaccines is already a familiar concept, there should be no problem with patients' compliance, and judicious partnerships between public and private organisations could mean the vaccines are produced cheaply.

The Millennium Development Goals (MDGs) practically define health efforts in the 21st century, but they virtually ignore non-communicable diseases such as mental health, say these authors. This is despite evidence that mental health disorders are among the most important cause of sickness and disability and even premature mortality. The authors argue that tackling mental health problems will be vital to achieving the MDGs, and three in particular — eradicating poverty, reducing child mortality, and improving maternal health.

Poverty and hunger are well-recognised risk factors for mental health, but mental health also makes it harder for people to escape the hunger trap. Mothers who are depressed during pregnancy and post natally, are more likely to have underweight babies; not only that, the illness means these mothers are more likely to stop breastfeeding and less likely to ensure their children are properly immunised than mothers without depression.

The authors advocate that strengthening basic health-care systems should be holistic. For example, developing countries need more and better-trained health workers but they should not only know how to deliver babies but also how to counsel new mothers. HIV/AIDS programmes, as another example, should ensure that individuals not only have good access to antiretrovirals but also to treatment for depression if they need it.

Worldwide, cancer kills more people than HIV/AIDS, malaria and TB put together. In developing countries where chronic diseases are now growing alongside infectious diseases, new strategies need to be developed.

This article outlines how to develop an effective cancer strategy in African countries on the basis of discussions at the recent African Cancer Reform convention. A cancer control plan clearly needs to take into account African countries' financial constraints and the authors outline six key essentials that would offer most health gain for money invested. These are: setting up cancer intelligence units to collect data on cancer incidence; controlling tobacco use; early diagnosis and prevention; offering treatment wherever possible; palliative care when treatment is no longer useful; and training and educating future generations of African oncologists.

Developed countries can offer crucial expertise and experience and collaborate on cancer information networks. Educating local communities about a disease that is relatively new but growing quickly will also be essential to stop it spiralling when many cancers are preventable or treatable when detected early enough.

In 2003, the Gates foundation infused new vigour into global health efforts by declaring that the 21st century's "grand challenges" included developing new vaccines and overcoming drug resistance. This new grand challenges initiative, launched by a collaboration of top global chronic disease experts, identifies priorities in tackling diseases like diabetes and cardiovascular disease, and explains in detail how research should be directed to meet each challenge (a challenge was defined as a critical barrier that if removed would help solve an important health problem).

To distill the range of opinions and priorities, the coordinators sought input from 155 stakeholders from different countries and disciplines. The initiative requires the participation of agencies like the WHO, individual governments, and non-governmental organisations as well as civil society and business if it is to succeed. The authors point out that the Gates initiative was linked to large funding, whereas this project will rely on multiple funding agencies to coordinate on these priorities.

Global health experts have watched with increasing alarm as the waistlines of people in developing countries have started to widen with the adoption of a "Western" lifestyle. Obesity is of such concern because of its heightened risks for other diseases, such as heart disease, cancer, and diabetes.

In developing countries, the number of people with diabetes is set to rise to 228 million by 2030 from 84 million estimated in 2000. The link between obesity and diabetes is so strong because obesity renders individuals unable to properly process glucose — about 90% of type 2 diabetes is due to being overweight. Obesity and diabetes also raise the risk for cardiovascular disease and kidney disease. Diabetic nephropathy was the most common cause of end-stage renal disease in 9 out of 10 Asian countries, say the authors, which could be deadly for countries unable to cope with the health repercussions.

This joint publication between the World Health Organization and the Global Forum for Health Research reveals mental health research capacity in 114 low-income and middle-income countries in Africa, Asia, and Latin America and the Caribbean. The extensive review identified over 10,000 articles, 4,633 mental health researchers and 3,829 other stakeholders. The authors argue that this is "the first systematic attempt to confirm the pressing needs of improving research capacity in mental health".

The publication provides useful details in table and charts, analysed by group of stakeholders and by region, on topics such as: researchers' profiles; priority-setting process; amount and type of research production; services and technical support available to them; courses and trainings offered; funding patterns; and dissemination of research findings. The appendix provides two extensive lists — by country — of policy and practice that resulted from research evidence, as well as research evidence that was never translated into policy and practice.

Nine recommendations indicate how the management of mental health research can be strengthened so that it meets the national needs of the countries as well as contributes to the global fund of knowledge. The authors say their report thus enables evidence-based decision-making in funding and priority setting in the area of mental health research in low-income and middle-income countries.

The WHO has provided its own estimates of how non-communicable diseases are set to rise in developing countries. These authors pool data from national registries and international databases to compare data on the differing burden from individual diseases. They outline the risk factors associated with the diseases.

The main three killers are cardiovascular disease, diabetes, and cancer. The paper ranks different types of cancer by how many people in developing countries they kill (lung and breast cancer are the deadliest) and also ranks diabetes prevalence by country (India, followed by China, has the highest prevalence).

To tackle these diseases, say the authors, people need to look closely at the risk factors in their life – eating healthily and exercising can do much to reduce the chances of getting one of these diseases.

This extensive report was one of the first to document the scale of the problem of chronic diseases in developing countries, and crucially, to offer guidance on feasible and practical methods of tackling them.

The document starts by laying out in detail the profiles of chronic diseases in different countries, projections for the future, and how chronic diseases are linked with poverty. It also examines in depth the economic costs of such diseases and the macroeconomic consequences of not tackling them quickly enough. The authors outline interventions — whether community, workplace, or school — that have robust evidence supporting them.

The report ends with a call for a unifying framework of global health experts and stakeholders, in which the government has a key role. It also specifies what policymakers need to do to ensure that measures to tackle chronic diseases are put into action.

This document presents the proceedings of a conference at the Royal Netherlands Academy of Arts and Sciences in December 2001. The conference papers deal with themes relating to the role of scientific research in the development of Northern countries and the need for North–South research cooperation. They document the experiences of research cooperation involving, among others, India, South Africa and a number of East African countries. Several papers deal with innovation and scientific cooperation, with case studies.

The report summarises the results of a survey of African Universities’ experiences in collaborating with scientists and institutions in developed countries. The study was carried out by the Association of Commonwealth Universities to provide background information to support the recent development thrust aimed at strengthening African universities through greater investment and North–South (and South–South) collaboration. It focuses primarily on social sciences and humanities research. The report presents empirical data on institutional goals, resource availability, prevalence and satisfaction with collaborative arrangements, challenges faced by individual researchers, capacity building as well as training and research support.