Skip Navigation

Agriculture & Environment: Agri-biotech

News

  • Print
  • Comment
  • | Share

GM cassava study retracted over 'missing' data

Zoraida Portillo

26 September 2012 | EN | ES

A woman carrying cassava

Cassava is grown widely in developing countries

FLICKR/IITA Image Library (International Institute of Tropical Agriculture)

[LIMA] A study that last year claimed to have found a way to boost the protein content of a staple crop rich in energy but poor in protein has been retracted after researchers failed to find any supporting data to back up its claims.

The study, published in PLoS ONE in January 2011, has been cited at least five times.

The authors claimed to have created a genetically modified (GM) cassava crop that expressed a gene called zeolin, thereby increasing the protein content by 12.5 per cent and potentially allowing the plant to become "capable of supplying inexpensive, plant-based proteins for food, feed and industrial applications".

But the study was retracted this month after the authors were unable to find the zeolin gene in plants from subsequent studies. The retraction notice says that "an institutional investigation revealed that significant amounts of data and supporting documentation that were claimed to be produced by the first author could not be found" and "the validity of the results could not be verified".

Cassava is a staple food in many developing countries, but its nutritional content — especially in protein and micronutrients — is low, something that the researchers from the Laboratory for Tropical Agricultural Biotechnology at the Donald Danforth Plant Science Center in the United States and Mayaguez University in Puerto Rico said they were on the verge of overcoming with the GM cassava.

The lead author of the article, Mohammad Abhary, left the Danforth Center in the middle of 2011, and the corresponding author Claude Fauquetdid not respond to SciDev.Net's requests for comment.

In a statement to Retraction Watch blog, Danforth president James Carrington, admitted that questions arose shortly after the paper was published, when the researchers tried to extend the findings.

Carrington said a more systematic analysis "indicated that the materials published in the paper were not as described, and that the materials that were described could not be found".

Rodomiro Ortiz, professor of plant breeding and biotechnology at the Swedish University of Agricultural Sciences, told SciDev.Net that the case confirms the need not only for rigor in initial research, but for experiments to be repeated before publication.

"It's unfortunate to come to this situation but [retraction] was necessary to keep the ethical values of scientific research," he added.

Ortiz, a breeder of several crops including cassava, had been sceptical when SciDev.Net asked him for an independent comment about this study in 2011, saying that the genetic material of wild and native cassava varieties should be further studied for cassava biofortification, instead of using genetic modification.

Link to the study and retraction

Comments (5)

ironjustice ( Canada )

27 September 2012

"its nutritional content — especially in protein and micronutrients — is low"

Dr. Hindhede during a blockade during the first world war proved a human being needs only one gram of protein intake for every ten pounds of body weight. The World Health Organisation says we need 3.5 grams per ten pounds body weight. Dr. Hindhede found a vegetarian need not worry about protein because they will get what little protein they need from the food they eat. A 'high protein cassava' is not required.

Mab_Sharkey ( CIAT | Colombia )

30 September 2012

The concept of "publish or perish" shouldnt be overemphasized in critical research such as GMO. Cassava is a starchy root crop with high productivity and photosynthetic potential. Also there are wide genetic diversity among cultivated germplasm and in related wild species , indicating the importance of taping through conventional breeding programs this naturally oocuring genetic diversity in improving the cassava crop.

M. A. El-Sharkawy, Retired senior scientist, CIAT, Cali, colombia

Nagib Nassar,Universidade Brasilia,Brasil ( Brazil )

30 September 2012

Congrates for Dr Carrrington, His courage , honesty and faithfullness to his scientific mission and his noble principles are highly appreciated by scientific community. As Rodomiro Ortiz said, Wild species and indigenous cultivars must have been exploited before running after molecular transformation to transfer bacteria and virus genes!! see a lot of information on wild cassava as resource of protein in www.geneconserve.pro.br and in publication of this researcher.

Nagib Nassar,Universidade Brasilia,Brasil ( Brazil )

1 October 2012

Wild Manihot species as a safety source of protein should have been exploited befoe looking to another unsafety aource in virus or bacteria and trying to transfer it by molecular means. So many successful work has been done on this subject by this author and his associates at the Universidade de Brasilia, through very low expensive projects supported by the Brazilian National Council of Research Development- CNPq, Brasilia and the Canadian International Research Development Center - IDRC. Not obly rich in Protein hybrids were obtained, but essential amino acids which do not occur in common cassava were reached. See for example this article published some five years ago in Genetics and Moleculkar Research :Amino acid profile in cassava and its interspecific hybrid by
Nagib M.A. Nassar1 and M.V. Sousa2
1Departamento de Genética e Morfologia, 2Departamento de Biologia Celular,
Universidade de Brasília, Brasília, DF, Brasil
Corresponding author: Nagib M.A. Nassar
E-mail: nagnassa@rudah.com.br
Genet. Mol. Res. 6 (2): 292-297 (2007)
The first publication on transferring high protein content from the wild was in 1982 (thirty years ago) by Nassar and Dorea in Turrialba as follows: Protein content of cassava cultivars and its hybrid with wild Manihot species
NMA Nassar, JG Dorea - Turrialba, 1982. The case of Wild Cassava rich in protein was documented in several publications in the decade 1970 by Nassar and co workers. For example publication in the leading Suisse Journal Experientia in 1977 as follows : NASSAR, NM A. and COSTA, C. 1977. Tuber formation and protein content in some wild
Manihot species native of Central Brazil. Experientia (Basel) 33: I304- I305

Pollyanna Gomes ( Brazil )

1 October 2012

In my MSc thesis, analysing protein content in cassava interspecific hybrids and their progenies developed by my supervisor Prof Nagib Nassar, Universidade de Brasilia, I could detect and select progenies which have protein content as high as 6,00 percent. Their essential amino acids profile revealed to be rich in amino acids normally absent in common cassava, such as arginin, methionin and tryptophane. In the meantime they showed very low HCN content which exclude any possibility of atribution to Nitrogen due to hydrocyanic acid hydrolysis. These results are expecting for publication at Journal of Food Composition and Analysis, Springer. This fact support what was said above that exploitation of the wild is necessary before looking for sources of protein in bacteria and virus genes.

Add your comment

This is your network: share your views on any of our articles by adding your comments.

You need to be signed in to post a comment or to email a consenting comment author. Please sign in or sign up.

All comments are subject to approval and we reserve the right to edit comments containing inappropriate/unsuitable language. SciDev.Net holds copyright for all material posted on the website. Please see terms of use for further details.

All SciDev.Net material is free to reproduce providing that the source and author are appropriately credited. For further details see Creative Commons.

Back to News
To the top